Diet Composition - Metabolic Regulation and Long-term Compliance (KNOTA)

Umeå University

Status: Completed

Conditions: Obesity

Treatments: Behavioral: NNR (Nordic Nutrition Recommendations); Behavioral: MPD (Modified paleolithic diet)

Study type: Interventional

Funder types: Other

Identifiers

NCT00692536

Um dnr 07-034M

Details and patient eligibility

About

This study will compare a high-protein/low-carbohydrate diet (modified paleolithic diet, MPD) with a diet high in slow carbohydrates (Nordic Nutrition Recommendations, NNR). The diets will be compared with respect effects on weight reduction, metabolic regulation, and long-term compliance to the diet regimes. Seventy-two postmenopausal overweight healthy women have been recruited and will be followed for two years.

The following variables will be studied:

• Anthropometry
• DEXA
• OGTT
• Liver fat content measured with 1H-MRS
• Hepatic 11β-HSD1 activity, measured with cortisone/cortisol conversion test

Enrollment: 70 patients

Sex: Female

Ages: Under 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Female
• Postmenopausal
• BMI>28

Exclusion criteria

• Disease
• Gravidity
• Smoking
• Prescribed medication

Trial design

70 participants in 2 patient groups

1

Active Comparator group

Description:

NNR

Treatment:

Behavioral: NNR (Nordic Nutrition Recommendations)

2

Active Comparator group

Description:

MPD

Treatment:

Behavioral: MPD (Modified paleolithic diet)