Diet, Genes and Colorectal Cancer - With Focus on Toll-like Receptor Polymorphisms

University of Southern Denmark (SDU)

Status: Completed

Conditions: Colorectal Cancer

Treatments: Other: Observational

Study type: Observational

Funder types: Other

Identifiers

NCT03250637

19-TLR

Details and patient eligibility

About

The aim of this study is to investigate the interaction between diet - primary meat and fiber - and polymorphisms in Toll-like receptors in relation to risk of colorectal cancer in a Danish prospective cohort.

Full description

Meat and dietary fibers have been associated with increased and decreased risk of colorectal cancer (CRC), respectively. Toll-like receptors (TLRs) regulate intestinal immune response in a complex interplay between the mucosal epithelium and the microbiota and may therefore be important modulators of diet-induced CRC and interact with other inflammatory mediators.

The aim of the study is to investigate the association with functional TLR polymorphisms in relation to risk of CRC and their interaction with dietary factors. Additionally, interactions with previously studied polymorphisms in IL10, IL1B, PTGS2 and NFKB1 will be assessed in order to examine possible biological pathways in meat-induced CRC.

Data are retrieved from the Danish prospective "Diet, Cancer and Health" study encompassing 57,053 persons which were recruited between 1993 to 1997. Between 1994 and 31th December 2009, 1038 CRC cases has been diagnosed. A sub-cohort of 1857 persons has been randomly selected within the full cohort at time of entry into the cohort. The study design is a nested case-cohort study.

Enrollment: 2,895 patients

Sex: All

Ages: 50 to 64 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Born in Denmark and had no previous cancers at study entry

Exclusion criteria

• Previous or present cancer(s) at study entry

Trial design

2,895 participants in 2 patient groups

Colorectal cancer cases

Description:

1038 participants diagnosed with colorectal cancer from the Diet, Cancer and Health cohort.

Treatment:

Other: Observational

Sub-cohort members

Description:

1857 persons randomly selected within the full cohort at time of entry into the Diet, Cancer and Health cohort. These participants serve as controls for the colorectal cancer cases.

Treatment:

Other: Observational