Diet Induced Intestinal Mucosal Adaptation

Göteborg University

Status: Completed

Conditions: Healthy Conditions

Treatments: Dietary Supplement: high fat diet (hfd), then high carbohydrate diet; Dietary Supplement: high carbohydrate diet, then high fat diet

Study type: Interventional

Funder types: Other

Identifiers

NCT02088853

BUTTER

Details and patient eligibility

About

Human beings are 'omnivores' meaning that all principal components of food (i.e. the macronutrients: carbohydrates, fat, proteins) can be assimilated by the gastrointestinal tract. When the gut mucosa is exposed to dietary changes it adjusts its functional behaviour. For example, a fatty diet demands certain digestive mechanisms, whereas others are needed to take care of a carbohydrate rich diet. Such dietary induced changes in appearance and functionality of the small intestinal mucosa have been described in animals but only little is known about it in man. The present project aims at elucidating in man if a 2 weeks diet dominated by either fat or carbohydrates, but with similar energy content, is associated with changes in the small intestinal mucosal appearance and metabolic signalling capacity.

Enrollment: 17 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

healthy volunteer not taking prescribed medications BMI ≤25 kg/m2

Exclusion criteria

BMI ≥26 kg/m2 smoker previous or current gastrointestinal disease significant abdominal surgery pregnancy/breast feeding drug intolerance of importance (particularly opiates and midazolam used during endoscopy) history of drug addiction

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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17 participants in 2 patient groups

First high fat diet, then high carbohydrate diet

Experimental group

Description:

had; first sixty percent fat as the energy source, then sixty percent carbohydrates

Treatment:

Dietary Supplement: high fat diet (hfd), then high carbohydrate diet

First, high carb diet, then high fat diet

Experimental group

Description:

had; first sixty percent carbohydrates as the energy source, the sixty percent fat

Treatment:

Dietary Supplement: high carbohydrate diet, then high fat diet