Diet Intervention in Food Sensitive Patients With IgA Nephropathy (DIIGA)

Uppsala University Hospital

Status: Unknown

Conditions: IGA Nephropathy

Treatments: Dietary Supplement: Tailored diet; Dietary Supplement: Low antigen content diet

Study type: Interventional

Funder types: Other

Identifiers

NCT01203007

SMR-2259

Details and patient eligibility

About

The purpose of this study is to assess whether a tailored diet, eliminating antigens to which IgA nephropathy patients have demonstrated sensitivity, will have an effect on proteinuria, renal function and other immunological variables.

Enrollment: 40 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Above 18 years
• IgA nephropathy (IgAN), verified by biopsy
• Proteinuria > 1 g/24 h
• Having signed informed consent form

Exclusion criteria

• Participation in another clinical trial
• Patients with celiac disease
• Introduction of an angiotensin-converting enzyme (ACE) inhibitor or angiotensin II receptor blockers (ARB) during the last three months prior to inclusion
• Patients treated with immunosuppressive or systemic corticosteroid drugs within the last twelve months

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

Tailored diet

Experimental group

Description:

Tailored diet according to demonstrated food sensitivity

Treatment:

Dietary Supplement: Tailored diet

Low-antigen content (LAC) diet

Experimental group

Description:

Low-antigen content diet

Treatment:

Dietary Supplement: Low antigen content diet