Diet Oil Induced Stimulation of GLP-1

University of Copenhagen

Status and phase: Completed; Early Phase 1

Conditions: Type 2 Diabetes Mellitus

Treatments: Dietary Supplement: Olive oil; Dietary Supplement: Diet oil; Dietary Supplement: Carrot

Study type: Interventional

Funder types: Other

Identifiers

NCT01453842

Diet oil

Details and patient eligibility

About

Activation of G protein-coupled receptor GPR119 stimulates glucagon-like peptide-1 (GLP-1)release from the intestinal L-cells. Previously, administration of 2-oleyl-glycerol (2-OG) to humans significantly increased plasma GLP-1. In the present study we want to test the effect in patients with type 2 diabetes. The hypothesis is that we will expect to find a significant increased plasma GLP-1 following a meal containing of 2-OG when compared to meals containing of olive oil or carbohydrates alone.

Full description

Activation of G protein-coupled receptor GPR119 stimulates glucagon-like peptide-1 (GLP-1)release from the intestinal L-cells. Previously, administration of 2-oleyl-glycerol (2-OG) to humans significantly increased plasma GLP-1. In the present study we want to test the effect in patients with type 2 diabetes. The hypothesis is that we will expect to find a significant increased plasma GLP-1 following a meal containing of 2-OG when compared to meals containing of olive oil or carbohydrates alone. The aim of the study is to elucidate the effect of 2-OG, 'diet oil' on GLP-1 secretion in patients with type 2 diabetes and to explain the mechanism behind the known stimulation of GLP-1 release by dietary fat.

Enrollment: 12 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with type 2 diabetes mellitus according to the WHO criteria
• caucasians
• age above 18 years
• BMI 20-30

Exclusion criteria

• kidney disease
• liver disease
• retinopathy
• anaemia
• use of insulin
• use of GLP-1 analogues
• use of DPP-4 inhibitors

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

---

12 participants in 3 patient groups, including a placebo group

Diet oil

Experimental group

Treatment:

Dietary Supplement: Diet oil

Olive oil

Active Comparator group

Treatment:

Dietary Supplement: Olive oil

Carrot

Placebo Comparator group

Treatment:

Dietary Supplement: Carrot