Dietary Effects on Circulating Lipoprotein-associated Phospholipase A2 (Lp-PLA2) Activity and Enzyme Activity in Peripheral Blood Mononuclear Cells (PBMCs) in Patients With Prediabetes or Newly Diagnosed Type 2 Diabetes
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About
We determined the effects of dietary intervention (replacement of refined rice with whole grains and legumes and a high intake of vegetables) on circulating Lp-PLA2 activity and enzyme activity in peripheral blood mononuclear cells (PBMCs) in patients with impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or newly-diagnosed type 2 diabetes.
Full description
Ninety-nine patients with impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or newly-diagnosed type 2 diabetes were randomly assigned to either a control group (usual diet with refined rice) or the whole grain group.
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Inclusion criteria
- Subjects who were in in impaired fasting glucose (IFG, 100≤ fasting glucose <126 mg/dL)
- or newly diagnosed type 2 diabetes (fasting glucose ≥126 mg/dL)
Exclusion criteria
- current and/or past history of cardiovascular disease including angina
- liver or kidney dysfunction
- thyroid or pituitary disease
- unstable weight loss/gain (≥2 kg) over the previous 12 months
- pregnancy or lactation
- taking medications or supplements
Trial design
Primary purpose
Allocation
Interventional model
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100 participants in 2 patient groups, including a placebo group
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Data sourced from clinicaltrials.gov
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