Dietary Intake of Alpha-linolenic Acid in Elderly

Assistance Publique - Hôpitaux de Paris

Status: Completed

Conditions: Inflammation; Metabolism Disorder, Lipid; Cardiovascular Diseases

Treatments: Dietary Supplement: Rapeseed oil; Dietary Supplement: Sunflower oil

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT03025620

Alphalinolenage

Details and patient eligibility

About

The purpose of this study is to evaluate the antiatherogenic and anti-inflammatory potential of an adequate intake of alpha-linolenic acid in elderly.

Full description

There is growing evidence that diets high in long chain n-3 polyunsaturated fatty acids (PUFA) decrease the risk of fatal ischemic heart disease.Both epidemiologic studies and clinical trials demonstrate substantial cardioprotective effects of alpha linolenic acid (ALA) from vegetable oils.However, little is known about the relation of the dietary intake of ALA with ischemic heart disease among older adults.In this study, elderly volunteers will be asked to ingest a supplement of a vegetable oil providing 1g of ALA, or an equivalent amount of linoleic acid as sunflower oil, for a diet period of 6 weeks.Serum samples will be collected before the dietary intervention and 6 weeks later.Plasma biomarkers of inflammatory, lipid cardiovascular risk factors and serum and red cell membrane fatty acid composition will be determined on all samples.

Enrollment: 254 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Elderly patients over 65 years old exhibiting clinical indices of cardiovascular disease
• Male or female
• Subjects who were hospitalized in the Geriatric Unit of the Emile Roux Hospital (AP-HP)
• MMSE (Mini Mental State Examination)score > or = 15
• Supervision available for study medication
• Able to ingest oral diet

Exclusion criteria

• Patients unable to understand the objectives of the dietary intervention
• Patients in paliative care
• Patients receiving supplement diets

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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254 participants in 2 patient groups, including a placebo group

Sunflower arm

Placebo Comparator group

Description:

Participants were supplied with the usual diet of the hospital, daily enriched with 17.5g fat as follows during 42 days: 10 g of sunflower oil (with a high content in linoleic acid) were added into the dinner soup and 7.5g delivered through a 12.5g portion of margarine made with sunflower oil (60% fat) that replaced butter on the breakfast toasts.

Treatment:

Dietary Supplement: Sunflower oil

Rapeseed arm

Active Comparator group

Description:

Participants were supplied with the usual diet of the hospital, daily enriched with 17.5g fat as follows during 42 days: 10 g of rapeseed oil (with a high content in alpha-linolenic acid) were added into the dinner soup and 7.5g delivered through a 12.5g portion of margarine made with rapeseed oil (60% fat) that replaced butter on the breakfast toasts.

Treatment:

Dietary Supplement: Rapeseed oil