Dietary Intake of Salmon and Bone Health

N

National Institute of Nutrition and Seafood Research, Norway

Status

Completed

Conditions

Osteoporosis

Treatments

Dietary Supplement: Tailor-made salmon with high levels of vitamin D3 and low K1
Dietary Supplement: Supplement with vitamin D and Calcium
Dietary Supplement: Tailor-made salmon with low levels of vitamin D3 and high K1
Dietary Supplement: Tailor-made salmon with high levels of vitamin D3 and K1

Study type

Interventional

Funder types

Other

Identifiers

NCT02615301
252.07

Details and patient eligibility

About

The aims of this study were to investigate how intake of tailor-made salmon affected bone biomarkers, nutritional status, as well as body composition and bone mineral density. The 122 healthy postmenopausal women included in this 12 weeks intervention study were randomized into four groups: three salmon groups (with three different vitamin D3/vitamin K1 combinations) and one tablet group (vitamin D and Calcium).

Full description

Suboptimal vitamin D status is common among humans, and might have a negative impact on bone health. Fatty fish, including Atlantic salmon, is an important dietary vitamin D source. However, due to a considerable change in fish feed composition, the contribution of vitamin D from salmon fillet has been reduced. The aims were to investigate how intake of tailor-made salmon affected bone biomarkers, nutritional status (vitamin D, omega-3), as well as body composition and bone mineral density (BMD). The 122 healthy postmenopausal women (median 55 years) included in this 12 weeks intervention study were randomized into four groups: three salmon groups (150 grams/two times/week) and one tablet group (800IU vitamin D and 1000 mg Calcium/day). The salmon groups also received calcium supplements (1000 mg/d). The salmon had three different vitamin D3/vitamin K1 combinations: high D3 + high K1, low D3 + high K1, or high D3 + low K1.

Enrollment

122 patients

Sex

Female

Ages

50 to 64 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Postmenopausal women
  • Caucasian ethnicity
  • Age range 50-65 years
  • Having postmenopausal age of at least one year

Exclusion criteria

  • Osteoporotic fractures
  • Medical treatment for osteoporosis
  • Warfarin treatment
  • Creatinine above or below normal range
  • Hypervitaminosis D
  • Malabsorption syndrome
  • Inflammatory bowel disease
  • Inflammatory rheumatic diseases
  • Women who had planned to go away on holiday during the intervention could not participate

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

122 participants in 4 patient groups

Salmon (HD+HK)
Experimental group
Description:
Tailor-made salmon with high levels of vitamin D3 and K1
Treatment:
Dietary Supplement: Tailor-made salmon with high levels of vitamin D3 and K1
Salmon (LD+HK)
Experimental group
Description:
Tailor-made salmon with low levels of vitamin D3 and high K1
Treatment:
Dietary Supplement: Tailor-made salmon with low levels of vitamin D3 and high K1
Salmon (HD+LK)
Experimental group
Description:
Tailor-made salmon with high levels of vitamin D3 and low K1
Treatment:
Dietary Supplement: Tailor-made salmon with high levels of vitamin D3 and low K1
Supplement (vitamin D + Calcium)
Experimental group
Description:
Supplement with vitamin D and Calcium
Treatment:
Dietary Supplement: Supplement with vitamin D and Calcium

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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