Dietary Interventions in Prediabetes

Mayo Clinic

Status: Completed

Conditions: Impaired Fasting Glucose; Pre Diabetes; Liver Fat

Treatments: Dietary Supplement: Dietary intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT01729078

12-003216

Details and patient eligibility

About

Assessment of glucose metabolism and liver fat after 12 week dietary intervention in pre diabetes subjects. Subjects will be randomized to either high fat (olive oil supplemented),high carb/high fiber (beans supplemented) and high carb/low fiber diets. Glucose metabolism will be assessed by labeled oral glucose tolerance test and liver fat by magnetic resonance spectroscopy pre randomization and at 8 and 12 week after starting dietary intervention.

Enrollment: 48 patients

Sex: All

Ages: 30 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Impaired fasting glucose(100-125 mg/dl)
• HbA1c 5.7-6.4 %
• BMI 26-40 kg/sq.m

Exclusion criteria

• MRS contraindication
• Pregnant women
• Liver disease

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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48 participants in 3 patient groups

high fat ( MUFA) diet

Experimental group

Description:

intervention using high fat diet.

Treatment:

Dietary Supplement: Dietary intervention

high carb/high fiber

Experimental group

Description:

diet using high carb-high fiber with dry beans

Treatment:

Dietary Supplement: Dietary intervention

high carb/low fat

Experimental group

Description:

Habitual diet

Treatment:

Dietary Supplement: Dietary intervention