Dietary Lipids as Primary Modulators of Carotenoid Absorption in Vegetables

Purdue University

Status: Completed

Conditions: Absorption of Carotenoids From Vegetables

Treatments: Other: Canola Oil; Other: Butter; Other: Soybean Oil

Study type: Interventional

Funder types: Other

Identifiers

NCT01006174

0707005641

Details and patient eligibility

About

The purpose of this research study is to determine how dietary fats and oils influence the absorption of beneficial plant pigments (carotenoids) from vegetables. The study will examine changes in blood carotenoids in response to eating a salad with different fats/oils.

Enrollment: 55 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age range: 18-50 years.
• Body mass index (BMI: weight (kg)/height (m2)) ranging from 20-29 kg/m²
• Weight stable (<4.5 kg change within the last 3 months),
• Constant habitual activity pattern, not to exceed activities of a recreational level over the past 3 months.
• Must be pre-menopausal
• Have clinically normal blood profiles (specifically normal liver and kidney functions and fasting blood glucose of ≤110 mg/dl)
• Non-smoking
• Non-diabetic
• No current or planned pregnancy
• Not using any hormone-based contraceptive, e.g., pill, patch, injection, implants, etc.
• No current use of medication affecting lipid profile
• No intestinal disorders including lipid malabsorption, lactose intolerance
• No heavy consumption of alcohol (>2 drinks per day)
• No current use of dietary supplements that affect cholesterol, (e.g. Benocol or fiber supplements) or a willingness to discontinue their use during the study.

Exclusion criteria

• Menopausal
• Diabetic
• Currently pregnant
• Currently using any type of hormone-based contraceptives, (e.g., pill, patch, injection, implants, etc.)
• Use of lipid altering medications

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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55 participants in 3 patient groups

A

Experimental group

Description:

Subjects will be assigned to consume 3 grams soybean oil, 8 grams canola oil, and 20 grams butter that is added to a salad.

Treatment:

Other: Soybean Oil

Other: Butter

Other: Canola Oil

B

Experimental group

Description:

Subjects will be assigned to consume 8 grams soybean oil, 20 grams canola oil, and 3 grams butter that is added to a salad.

Treatment:

Other: Soybean Oil

Other: Butter

Other: Canola Oil

C

Experimental group

Description:

Subjects will be assigned to consume 20 grams soybean oil, 3 grams canola oil, and 8 grams butter that is added to a salad.

Treatment:

Other: Soybean Oil

Other: Butter

Other: Canola Oil