Dietary Lipids as Primary Modulators of Carotenoid Absorption in Vegetables

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Purdue University

Status

Completed

Conditions

Absorption of Carotenoids From Vegetables

Treatments

Other: Canola Oil
Other: Butter
Other: Soybean Oil

Study type

Interventional

Funder types

Other

Identifiers

NCT01006174
0707005641

Details and patient eligibility

About

The purpose of this research study is to determine how dietary fats and oils influence the absorption of beneficial plant pigments (carotenoids) from vegetables. The study will examine changes in blood carotenoids in response to eating a salad with different fats/oils.

Enrollment

55 patients

Sex

All

Ages

18 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Age range: 18-50 years.
  • Body mass index (BMI: weight (kg)/height (m2)) ranging from 20-29 kg/m²
  • Weight stable (<4.5 kg change within the last 3 months),
  • Constant habitual activity pattern, not to exceed activities of a recreational level over the past 3 months.
  • Must be pre-menopausal
  • Have clinically normal blood profiles (specifically normal liver and kidney functions and fasting blood glucose of ≤110 mg/dl)
  • Non-smoking
  • Non-diabetic
  • No current or planned pregnancy
  • Not using any hormone-based contraceptive, e.g., pill, patch, injection, implants, etc.
  • No current use of medication affecting lipid profile
  • No intestinal disorders including lipid malabsorption, lactose intolerance
  • No heavy consumption of alcohol (>2 drinks per day)
  • No current use of dietary supplements that affect cholesterol, (e.g. Benocol or fiber supplements) or a willingness to discontinue their use during the study.

Exclusion criteria

  • Menopausal
  • Diabetic
  • Currently pregnant
  • Currently using any type of hormone-based contraceptives, (e.g., pill, patch, injection, implants, etc.)
  • Use of lipid altering medications

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

55 participants in 3 patient groups

A
Experimental group
Description:
Subjects will be assigned to consume 3 grams soybean oil, 8 grams canola oil, and 20 grams butter that is added to a salad.
Treatment:
Other: Soybean Oil
Other: Butter
Other: Canola Oil
B
Experimental group
Description:
Subjects will be assigned to consume 8 grams soybean oil, 20 grams canola oil, and 3 grams butter that is added to a salad.
Treatment:
Other: Soybean Oil
Other: Butter
Other: Canola Oil
C
Experimental group
Description:
Subjects will be assigned to consume 20 grams soybean oil, 3 grams canola oil, and 8 grams butter that is added to a salad.
Treatment:
Other: Soybean Oil
Other: Butter
Other: Canola Oil

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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