Dietary Nitrate in COPD (CHB-BRJ-COPD)

Royal College of Surgeons, Ireland

Status: Completed

Conditions: Chronic Obstructive Pulmonary Disease

Treatments: Dietary Supplement: Nitrate rich beverage; Dietary Supplement: Nitrate free beverage

Study type: Interventional

Funder types: Other

Identifiers

NCT02148289

CHB-BRJ-COPD

Details and patient eligibility

About

The acute consumption of dietary nitrate has been shown to improve exercise capacity in athletes, healthy adults and subjects with peripheral vascular disease. Many COPD patients have reduced exercise capacity, The investigators hypothesized that acute nitrate consumption, in the form of beetroot juice, might increase incremental shuttle walk test (ISWT) distance in COPD subjects.

Full description

Acute consumption of dietary nitrate (as beetroot juice) has been shown to improve exercise capacity in athletes, healthy adults and subjects with peripheral vascular disease. Many COPD patients have reduced exercise capacity, The investigators hypothesized that acute nitrate consumption might increase incremental shuttle walk test (ISWT) distance in COPD subjects compared to a matched, low-nitrate drink.

This study is a randomized, double-blind placebo-controlled, crossover trial.

Resting blood pressure, phlebotomy and ISWT are performed. Following completion, each subject is randomized to consume beetroot juice or placebo. 3 hours later, the same assessments are repeated by the same people. After a 7d washout, the entire protocol is repeated with the crossover beverage.

Enrollment: 12 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Information consenting out-patients with a previous physician diagnosis of COPD
• Clinically stable
• Ambulatory

Exclusion criteria

• Subjects who required supplemental oxygen for exercise
• Subjects with pulmonary hypertension and angina
• Intolerant to beetroot
• Insulin dependent diabetes
• Thyroid disease

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

---

12 participants in 2 patient groups, including a placebo group

Nitrate rich beverage

Active Comparator group

Description:

Nitrate rich beverage will contain 140ml nitrate rich beetroot juice + 200ml blackcurrant juice containing 12.7mmol nitrate

Treatment:

Dietary Supplement: Nitrate rich beverage

Nitrate free beverage

Placebo Comparator group

Description:

Nitrate free beverage will 140ml water + 200ml blackcurrant juice containing \<0.5mmol nitrate

Treatment:

Dietary Supplement: Nitrate free beverage