Dietary Nucleotides and Ribose on Muscle Fuel Utilisation (FUN)

University of Exeter

Status: Completed

Conditions: Healthy

Treatments: Dietary Supplement: High nucletide + Ribose; Dietary Supplement: High nucleotide; Dietary Supplement: Low nucleotide

Study type: Interventional

Funder types: Other

Identifiers

NCT03659890

171206/B/04

Details and patient eligibility

About

Nucleotides are the building blocks for a variety of molecules, including ATP, which is broken down in the skeletal muscle cells to provide fuel for exercise. Nucleotides can be obtained from the diet, and produced or salvaged by the body. Though nucleotides provide the building blocks for ATP, the sugar ribose has been suggested to be rate limiting for synthesising ATP.

Previous studies have shown a decrease in ATP levels in the muscle after intense exercise, and this is linked to fatigue. Other studies have also reported benefits of nucleotide and/or ribose supplementation on exercise performance. However, any potential link between ATP metabolism and exercise performance has not been explored.

This study will look at the effects of nucleotide and nucleotide-ribose supplementation in fuel utilisation and performance in skeletal muscle during endurance exercise.

Enrollment: 13 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI between 18 and 30

Exclusion criteria

• On medication (except contraception)
• Smokers
• Diagnosed with any metabolic or cardiovascular conditions
• Muscle or bone injuries
• BMI < 18 or > 30

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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13 participants in 3 patient groups, including a placebo group

Low nucleotide

Placebo Comparator group

Description:

2 week supplementation with a low nucleotide mycoprotein drink, with added dextrose

Treatment:

Dietary Supplement: Low nucleotide

High nucleotide

Experimental group

Description:

2 week supplementation with a high nucleotide mycoprotein drink, with added dextrose

Treatment:

Dietary Supplement: High nucleotide

High nucletide + Ribose

Experimental group

Description:

2 week supplementation with a high nucleotide mycoprotein drink, with added ribose

Treatment:

Dietary Supplement: High nucletide + Ribose