Dietary Oils to Sustain Energy Study (DOSE)

The Ohio State University

Status

Active, not recruiting

Conditions

Overweight and Obesity

Treatments

Other: Soybean Oil Foods

Other: Palm Oil Foods

Study type

Interventional

Funder types

Other

Identifiers

NCT04975763

2021H0232

Details and patient eligibility

About

The research study is an intervention and feasibility crossover design pilot study designed to assess if consuming 3 study foods made with either soybean oil or palm oil per day for 4 weeks can alter whole blood, plasma and erythrocyte fatty acids and body weight in overweight/obese adults. Additionally, the study will assess the adherence to consuming 3 study foods per day for 4 weeks and to assess if participant remain unaware of (or masked to) which study food group (soybean oil vs palm oil) they are consuming.

Full description

The objectives of the study include

To determine changes in whole blood, plasma and erythrocyte linoleic acid after 4 weeks of consuming 3 foods products made soybean oil and determine changes in plasma and erythrocyte oleic acid and palmitic acid after 4 weeks of consuming 3 food products per day made with palm oil in overweight/obese adults
To determine changes in body weight in overweight/obese adults during four weeks of consuming 3 food products per day made with soybean oil and during four weeks of consuming 3 food products per day made with palm oil
To determine if there is evidence of unmasking of the two food product groups (soybean oil or palm oil) during the study in participants and in study coordinators
To determine adherence of consuming 3 food products per day made with either soybean or palm oil for 4 weeks in overweight/obese adults

Enrollment

16 estimated patients

Sex

All

Ages

25 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age 25-80 years old
Nonsmokers
BMI 25-55 kg/m2

Exclusion criteria

Current or previous diagnosis of heart, kidney, and some liver diseases
Current or previous diagnosis some circulatory diseases and some autoimmune diseases
Treatment of current cancer diagnosis or current cancer diagnosis
Current or previous diagnosis of diabetes
Gastrointestinal diseases or disorders (including pancreatic) that influence nutrient digestion and absorption or gastric bypass surgery
Alcohol or drug abuse
Inability to access veins for venipuncture
Hypothyroidism or Hyperthyroidism diagnosis
Food Allergy or intolerances
Any dietary restriction where consumption of the study foods or any ingredient would be contraindicated
Use of medications where consuming the study foods would be contraindicated
Use of supplements or medications for weight loss or following a weight loss program
Use of supplements high in linoleic acid in the past 4 weeks prior to enrolling
Pregnancy and lactation