Dietary Peanuts and Nutrition-Related Outcomes

Ian J. Neeland, MD

Status: Not yet enrolling

Conditions: Food Acceptance; Obesity & Overweight; Dietary Change

Treatments: Procedure: Dual-energy X-ray absorptiometry (DEXA) scans; Dietary Supplement: Peanuts

Study type: Interventional

Funder types: Other

Identifiers

NCT07244458

STUDY20250426

Details and patient eligibility

About

This study will look at how eating peanuts every day might affect participants weight, how healthy their diet is, and how they feel when eating. Investigators want to see if adding peanuts to meals for 12 weeks helps participants feel fuller, have more energy, and improve body composition. The study will include adults who have been taking GLP-1 medicines like semaglutide or tirzepatide for at least three months. Investigators also want to see if eating peanuts improves overall diet quality and health markers like tiredness and certain levels in blood.

Enrollment: 64 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Individuals with a BMI ≥30 kg/m2 who intend to be continuously using semaglutide or tirzepatide for a clinical indication and remain on the therapy for at least 6 months

Exclusion criteria

• No use or contraindication to use of a GLP-1 RA
• Known allergy to nuts
• Pregnant or breastfeeding
• Incarcerated

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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64 participants in 2 patient groups

Peanut Group

Experimental group

Description:

Participants in this group will eat 2 ounces, or 53 grams of dry-roasted, lightly salted (low sodium) each day along with their regular diet.

Treatment:

Dietary Supplement: Peanuts

Procedure: Dual-energy X-ray absorptiometry (DEXA) scans

No Peanut Group

Active Comparator group

Description:

Participants in this group will continue eating regular diet without peanuts.

Treatment:

Procedure: Dual-energy X-ray absorptiometry (DEXA) scans