Dietary Protein and Resistance Exercise in Elderly (NUTRIAGINGPROT)

University of Vienna

Status: Unknown

Conditions: Aging

Treatments: Other: High protein intake; Other: Strength training; Other: Low protein intake; Other: Control, no intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT04023513

FA219002

Details and patient eligibility

About

The aim of this randomized, observer-blind, controlled intervention study with parallel groups is to study the effect of resistance training (2x/week for 8 weeks) with and without different goals of protein intake on muscle strength, function and mass, oxidative stress parameters and the immune system in community dwelling persons.

Participants (n = 137) will be community-dwelling older adults. After a pre-participation screening participants will be distributed randomly but stratified by sex and age to one of the 3 groups (low protein + strength training, high protein + strength training, low protein and no strength training(=control)). Study participants are eligible if they are male or female with an age between 65 and 85 years and if their cognitive status as well as their physical fitness level allows to participate at the strength training sessions. Exclusion criteria comprise chronic diseases which contraindicate the training sessions, serious cardiovascular disease, diabetic retinopathy and manifest osteoporosis, a frailty index at or above 3, medication with anticoagulants or cortisone drugs and also regular strength training during the last six months.

Primary outcome measure is the change in the Chair Stand Test. Secondary outcome measures comprise anthropometric data, functional performance tests, immunological and oxidative stress parameters, microbiota, metabolomics, proteomics and the nutritional status.

Enrollment: 137 patients

Sex: All

Ages: 65 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Males and females between the age of 65 and 85 years of age
• Adequate mental condition in order to follow the instructions and to perform the resistance exercise independently (Mini-Mental-State >23)
• Independently mobile

Exclusion criteria

• Chronic diseases, which contraindicate a training participation
• Serious cardiovascular diseases (congestive chronic heart failure, severe or symptomatic aortic stenosis, unstable angina pectoris, untreated arterial hypertension, cardiac arrhythmias)
• Diabetic retinopathy
• Manifest osteoporosis
• Regular use of cortisone-containing drugs
• Regular strength training (> 1x / week) in the last 6 months before inclusion

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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137 participants in 3 patient groups

Strength Training and Protein high

Experimental group

Description:

6 weeks of high protein intake (additional 1g/kg bw/d) followed by a 8 weeks resistance training (Progressive strength training in a fitness center is applied; the intensity is adjusted continuously in order to obtain a sufficient training stimulus). During the training period the protein intake remains.

Treatment:

Other: High protein intake

Other: Strength training

Strength Training and Protein low

Experimental group

Description:

6 weeks of low protein intake (1g/kg bw/d) followed by a 8 weeks resistance training (Progressive strength training in a fitness center is applied; the intensity is adjusted continuously in order to obtain a sufficient training stimulus). During the training period the protein intake remains.

Treatment:

Other: Low protein intake

Other: Strength training

Control

Other group

Description:

No Intervention.

Treatment:

Other: Control, no intervention