Dietry Pattern and Lead Levels in Pregnancy

University of Bristol

Status: Completed

Conditions: Dietary Habits; Pregnancy Related; Lead Poisoning

Treatments: Other: None - observational

Study type: Observational

Funder types: Other

Identifiers

NCT03408275

ALSPAC_2

Details and patient eligibility

About

During pregnancy lead crosses the placenta freely and can have adverse effects on the fetus, with the potential for life-long impact on the child. Identification of dietary patterns and food groups in pregnancy in relation to measures of lead status could provide a more useful alternative to a nutrient-specific advice to minimise fetal exposure to lead during pregnancy. The aim is to evaluate whether dietary patterns and food groups are associated with blood lead concentrations in pregnancy.

Full description

Whole blood samples were collected from pregnant women enrolled in the Avon Longitudinal Study of Parents and Children observational birth cohort study and were analysed for lead. Dietary pattern scores were derived from principal components analysis of a food frequency questionnaire. Associations of quartiles of dietary pattern scores, and of food groups categorised by frequency of consumption, with the likelihood of blood lead concentration (B-Pb) ≥5 µg/dl will be identified with adjusted logistic regression (n=2167).

Enrollment: 2,167 patients

Sex: Female

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: Enrolled in ALSPAC, pregnant -

Exclusion Criteria: Not enrolled in ALSPAC, not pregnant

Trial design

2,167 participants in 1 patient group

Pregnant women

Description:

Pregnant women enrolled in ALSPAC

Treatment:

Other: None - observational

Sponsors of this trial

Lead Sponsor

University of Bristol

Collaborating Sponsors

United Kingdom Research and Innovation (UKRI)

Wellcome

Bristol Biomedical Research Unit