Difference Between Inhalation Anesthesia and Total Intravenous Anesthesia in Free Flap Surgery

Taichung Veterans General Hospital

Status: Completed

Conditions: Surgery

Treatments: Drug: Propofol; Drug: Sevoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT03263078

CF16113B

Details and patient eligibility

About

The purpose of this study is to compare the difference between total intravenous anesthesia to inhaled anesthesia in free flap surgery.

Full description

The aim of this study is to perform a randomized controlled trial to examine the effects of different anesthetics on intraoperative hemodynamic stability during free flap surgery and postoperative complications

Enrollment: 78 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Patients who need head and neck cancer excision and free flap reconstruction surgery

Exclusion criteria

1. preoperative cognitive dysfunction, NYHA CHF > III or LVEF < 30%
2. preoperative documented obstructive or restrictive lung disease
3. liver cirrhosis; severe chronic renal insufficiency (GFR < 30 ml·min-1·1.73 m-2.)
4. peripheral arterial occlusive disease expected to be a contraindication for PiCCO catheter insertion
5. Active cardiac arrhythmias that were assumed to preclude valid assessment using arterial pulse contour analysis
6. anticipated bilateral femoral arterial and central venous catheterization when the jugular and subclavian veins were not available due to surgical extent

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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78 participants in 2 patient groups

TIVA with Propofol in free flap surgery

Experimental group

Description:

Total intravenous anesthesia(TIVA) with Propofol

Treatment:

Drug: Propofol

Sevoflurane in free flap surgery

Active Comparator group

Description:

Inhalation anesthesia with Sevoflurane

Treatment:

Drug: Sevoflurane