Difference of Tear Ferning Between Women with and Without Menopausal.

Chung Shan Medical University

Status: Enrolling

Conditions: Dry Eye Syndromes

Treatments: Other: Pre-manepausal women

Study type: Interventional

Funder types: Other

Identifiers

NCT06848829

202400071B0

Details and patient eligibility

About

Application of tear ferning test for clinical dry eye diagnosis and menopause

Full description

Analyzing the difference in tear ferning structure between women pre and post-menopause with and without hormone replacement therapy (HRT). Tear and blood samples were collected for a menopause-related Enzyme-linked immunosorbent assay. Tear volume, tear osmolarity, intraocular pressure, and tear break-up time were also measured for comparison.

Enrollment: 90 estimated patients

Sex: Female

Ages: 20 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Aged between 20 and 65 years

Exclusion criteria

• No evident ocular diseases such as cornea, cataracts, vitreous degeneration, glaucoma, and retinopathy.
• Belong to vulnerable groups(pregnancy woman, prisoner, ethical minorities, economic or educationally disadvantaged subjects, disabled individuals such as those at terminal stage of tumorigenesis, blindness, terminal ill individuals)

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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90 participants in 2 patient groups

Pre-manepausal women

No Intervention group

Description:

Collect clinical information, tear and blood samples from women pre-menopause with dry eye syndrome.

Post-manepausal women

Other group

Description:

Collect clinical information, tear and blood samples from women post-menopause with dry eye syndrome.

Treatment:

Other: Pre-manepausal women