Differences in Brain Derived Neurotrophic Factor Levels Between Chronic and Asymptomatic Pain Patients (BDNF)

Universidad Autonoma de Madrid

Status: Enrolling

Conditions: Chronic Pain

Treatments: Genetic: BDNF analysis (Elisa KIT)

Study type: Observational

Funder types: Other

Identifiers

NCT05736575

CCBDNF

Details and patient eligibility

About

A case-control study will be conducted to analyze the differences in BDNF levels between patients with chronic pain and asymptomatic people.

Full description

Brain-derived neurotrophic factor (BDNF) is considered a biomarker of brain plasticity. Since different alterations in brain plasticity have been found in chronic pain patients, the investigators want to study whether there are differences at the molecular level in this population compared to an asymptomatic population in order to be able to accurately measure the impact of different physiotherapy interventions in an objective way.

Enrollment: 66 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• males and females aged 18 to 65 years with musculoskeletal pain for a minimum of 3 months
• patients recruited by information pamphlets from the university clinic of the Rey Juan Carlos University, and CSEU La Salle
• not having received physiotherapy treatment for this same process in the last 3 months.
• ability to perform all the clinical tests and to understand the study process, as well as to obtain informed consent.

Exclusion criteria

• Systemic, neurological, oncological or inflammatory diseases; psychiatric pathologies, pregnancy, type II diabetes.

Trial design

66 participants in 2 patient groups

Chronic Pain Patient

Description:

A blood draw is to be performed to analyze peripheral BDNF.

Treatment:

Genetic: BDNF analysis (Elisa KIT)

Asymptomatic subject

Description:

A blood draw is to be performed to analyze peripheral BDNF.

Treatment:

Genetic: BDNF analysis (Elisa KIT)