Differences in ECG- vs. proLonged cardIac MonItor-DeTected Atrial Fibrillation in STROKE Patients (DELIMIT AF-STROKE)

Lawson Health Research Institute

Status: Active, not recruiting

Conditions: TIA; Atrial Fibrillation; Stroke

Treatments: Diagnostic Test: Prolonged cardiac monitoring; Diagnostic Test: ECG

Study type: Observational

Funder types: Other

Identifiers

NCT05822791

ReDA ID 13446

Details and patient eligibility

About

The present study is an investigator-initiated, single-center, retrospective study based on data from the London Ontario Stroke Registry (LOSR), aiming to compare the characteristics and outcomes of ECG-detected and Device-Detected atrial fibrillation in patients with ischemic stroke and transient ischemic attack.

Full description

Patients with ischemic stroke and transient ischemic attack (TIA) without known atrial fibrillation (AF) are investigated with Prolonged Cardiac Monitoring (PCM) to detect AF. It is unclear if AF detected on 12-lead ECG after stroke occurrence bears the same risk of stroke as Device-detected AF. The investigators hypothesize, that Device-detected AF has a lower risk of ischemic stroke recurrence. The investigators will conduct a retrospective analysis of prospectively collected data from consecutive patients enrolled in the London Ontario Stroke Registry, (Ontario, Canada). The primary outcome will be a recurrent ischemic stroke at the end of the available follow-up window. The investigators will include ischemic stroke and TIA patients with ECG-detected AF and those with Device-detected AF on at least 7 days of Holter monitoring.

Enrollment: 366 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥18 years
• Patient with a diagnosis of ischemic stroke or TIA.
• ECG-diagnosed AF or PCM-detected AF post ischemic stroke or TIA

Exclusion criteria

• Individuals younger than18 years-old
• Patients without IS or TIA diagnosis

Trial design

366 participants in 2 patient groups

ECG-Detected AF

Description:

Patients with atrial fibrillation detected on 12-lead ECGs done post-stroke

Treatment:

Diagnostic Test: ECG

Device-Detected AF

Description:

Patients with atrial fibrillation detected on prolonged Holter monitoring lasting at least 7 days.

Treatment:

Diagnostic Test: Prolonged cardiac monitoring