Differences in Immunologic Response to Cryoablation Versus Radiofrequency Ablation in the Treatment of Renal Cell Carcinoma

University of California Irvine (UCI)

Status: Terminated

Conditions: Immune Response to 3 Approaches

Study type: Observational

Funder types: Other

Identifiers

NCT03409224

2009-6735

Details and patient eligibility

About

The purpose of this study is to compare changes in the body's self-defense (immune response) after two different treatments for small kidney tumors: 1) Cryoablation (freezing) therapy in which the tumor and a margin of normal kidney tissue are frozen and thawed twice with a needle probe and 2) radiofrequency ablation (RFA) in which radiofrequency energy delivered through a needle probe is used to heat tissue and thereby destroy a tumor.

Enrollment: 53 patients

Sex: Male

Ages: 18 to 99 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• You are eligible to participate in this study if you are an adult (older than 18 years)
• Diagnosed with renal cell cancer 1-3 centimeters in size on the CT scan.

Exclusion criteria

• You are not eligible to participate in this study if you are immune compromised (chemotherapy,corticosteroid use, HIV [as documented in your medical record], etc.)
• Have an autoimmune disorders (Rheumatoid arthritis, Crohn's disease, etc)
• Have a tumor larger than 4 cm
• Are pregnant.

Trial design

53 participants in 1 patient group

Adults 18-99

Description:

Adults who are undergoing cryoablation