Different Administration Routes of Dexmedetomidine on Postoperative Delirium

Shenzhen United Scheme Technology

Status: Enrolling

Conditions: Dexmedetomidine; General Anesthesia; Postoperative Delirium

Treatments: Drug: Dexmedetomidine

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT05952050

US2023001

Details and patient eligibility

About

Intravenous dexmedetomidine has been reported to decrease the occurrence of postoperative delirium (POD) in elderly patients. Nevertheless, some previous studies have indicated that intratracheal dexmedetomidine and intranasal dexmedetomidine are also effective and convenient. The current study aimed to compare the effect of different administration routes of dexmedetomidine on POD in elderly patients.

Enrollment: 120 estimated patients

Sex: All

Ages: 65 to 99 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Older than 65 years; General anesthesia for more than two hours;

Exclusion criteria

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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120 participants in 2 patient groups

Intranasal dexmedetomidine

Experimental group

Treatment:

Drug: Dexmedetomidine

Intravenous dexmedetomidine

Active Comparator group

Treatment:

Drug: Dexmedetomidine