Different Anesthetic Managements of Esophageal Resection and Reconstruction

National Taiwan University

Status: Unknown

Conditions: Postoperative Complications; Esophagus Cancer; Anesthesia

Treatments: Other: Cardiac Output Normalization; Other: Cardiac Output Maximization

Study type: Interventional

Funder types: Other

Identifiers

NCT02961140

201512052RINB

Details and patient eligibility

About

Anesthetic management and fluid therapy is crucial in esophageal resection and reconstruction, which is associated with high incidence of postoperative morbidity and mortality. This study aims to investigate the effect of goal directed fluid management on the postoperative outcome of esophageal resection and reconstruction.

Full description

Anesthetic management and fluid therapy is crucial in esophageal resection and reconstruction, which is associated with high incidence of postoperative morbidity and mortality. Excessive fluid administration may result in pulmonary complication, while extremely hypovolemia may lead to shock, circulatory dysfunction, and renal damage. Little is known about fluid status will have impact on anastomotic leakage. Goal-directed fluid therapy has shown to benefit perioperative outcome in major abdominal surgery. This study aims to investigate the effect of goal directed fluid management on the postoperative outcome of esophageal resection and reconstruction.

Enrollment: 60 estimated patients

Sex: All

Ages: 35 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients diagnosed as esophageal cancer
• Scheduled for minimally invasive esophageal resection and reconstruction

Exclusion criteria

• End-stage organ dysfunction, including heart failure, hepatic failure, renal failure
• Arrhythmia
• Pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups

Cardiac Output Maximization

Experimental group

Description:

maximize stroke volume, and maintain cardiac index and stroke volume variation during the whole operation

Treatment:

Other: Cardiac Output Maximization

Cardiac Output Normalization

Active Comparator group

Description:

keep cardiac index (CI) ≥ 2.2, and maintain CI and stroke volume variation during the whole operation

Treatment:

Other: Cardiac Output Normalization