Different Antihypertensive Drugs on Aortic Diseases (DADAD)

Eighth Affiliated Hospital, Sun Yat-sen University

Status: Completed

Conditions: Aortic Aneurysm; Aortic Dissection

Treatments: Drug: non-CCB use; Drug: CCB use

Study type: Observational

Funder types: Other

Identifiers

NCT06626607

ZB-KYIRB-AF/SC-08/02.0

Details and patient eligibility

About

The goal of this observational study is to learn about the effect of different hypotensive drugs on the prognosis of postoperative aortic patients. The main question it aims to answer is:

Does different hypotensive drugs influence the prognosis of postoperative aortic patients? As participants already taking hypotensive drugs as part of their regular medical care, the investigators collect the participants' pre-operation medical record and post-operative follow-up record to evaluate the aorta condition.

Full description

This study is a cohort study that aims to explore the effects of different antihypertensive regimens on aortic remodelling in patients after aortic surgery by collecting the hospitalization and outpatient follow-up data. The study plans to gather perioperative and postoperative follow-up data from over 600 patients who underwent aortic surgery at the Eighth Affiliated Hospital and Beijing Anzhen Cardiothoracic Surgery Center. Patients were assigned based on the postoperative antihypertensive medication regimens. Datas was collected to compare the cardiovascular-related prognoses.

This study primarily includes patients who take oral antihypertensive medications after aortic surgery. The main observations will focus on postoperative complications related to the aorta (such as death, reoperation, dilation, etc.) and aortic diameters after the administration of different antihypertensive medications. Multivariate regression analysis will be employed to investigate the impact of different antihypertensive regimens on patients after aortic surgery.

Enrollment: 704 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• aortic diseases' patients underwent aortic surgery who require antihypertensive medication.

Exclusion criteria

• Patients with active vasculitis;
• Patients allergic to contrast agent
• Patients with aorta variation

Trial design

704 participants in 2 patient groups

CCB group

Description:

Patients' postoperative antihypertensive includes CCB (Calcium Calcium Entry Blockers)

Treatment:

Drug: CCB use

non-CCB group

Description:

Patients' postoperative antihypertensive does not include CCB

Treatment:

Drug: non-CCB use