Different Doses of vPDT in the Treatment of cCSC

Peking University

Status: Unknown

Conditions: Therapy, Photodynamic; Central Serous Chorioretinopathy

Treatments: Procedure: 70% dose of photodynamic therapy; Procedure: 50% dose of photodynamic therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT05390619

RDL2020-04

Details and patient eligibility

About

This is a prospective, randomized and controlled clinical trial of photodynamic therapy (PDT) for chronic central serous chorioretinopathy (CSC). The patients who met the inclusion criteria were randomly divided into 50% dose PDT treatment group and 70% dose PDT treatment group. The primary treatment success rate and adverse event rate of the two groups were compared by optical coherence tomography (OCT), and then the best PDT treatment scheme for chronic CSC was summarized.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18-75 years old, regardless of gender;
• Meet the diagnostic criteria of central serous chorioretinopathy;
• The course of CSC (subject to the symptoms of this disease) is more than 3 months;
• Patients with simultaneous diseases of both eyes were included in those with more subretinal fluid.

Exclusion criteria

• macular neuroretinal detachment caused by rhegmatogenous retinal detachment, uveitis, age-related macular degeneration, polypoid choroidal angiopathy and other fundus diseases;
• a previous history of PDT treatment;
• systemic hormone or local hormone nasal spray is being used, or hormone is stopped for less than 3 months.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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100 participants in 2 patient groups

50% dose of PDT

Experimental group

Description:

Patients received 50% dose of verteporfin PDT therapy.

Treatment:

Procedure: 50% dose of photodynamic therapy

70% dose of PDT

Experimental group

Description:

Patients received 70% dose of verteporfin PDT therapy.

Treatment:

Procedure: 70% dose of photodynamic therapy