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Different Doses of vPDT in the Treatment of cCSC

P

Peking University

Status

Unknown

Conditions

Therapy, Photodynamic
Central Serous Chorioretinopathy

Treatments

Procedure: 70% dose of photodynamic therapy
Procedure: 50% dose of photodynamic therapy

Study type

Interventional

Funder types

Other

Identifiers

NCT05390619
RDL2020-04

Details and patient eligibility

About

This is a prospective, randomized and controlled clinical trial of photodynamic therapy (PDT) for chronic central serous chorioretinopathy (CSC). The patients who met the inclusion criteria were randomly divided into 50% dose PDT treatment group and 70% dose PDT treatment group. The primary treatment success rate and adverse event rate of the two groups were compared by optical coherence tomography (OCT), and then the best PDT treatment scheme for chronic CSC was summarized.

Enrollment

100 estimated patients

Sex

All

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • 18-75 years old, regardless of gender;
  • Meet the diagnostic criteria of central serous chorioretinopathy;
  • The course of CSC (subject to the symptoms of this disease) is more than 3 months;
  • Patients with simultaneous diseases of both eyes were included in those with more subretinal fluid.

Exclusion criteria

  • macular neuroretinal detachment caused by rhegmatogenous retinal detachment, uveitis, age-related macular degeneration, polypoid choroidal angiopathy and other fundus diseases;
  • a previous history of PDT treatment;
  • systemic hormone or local hormone nasal spray is being used, or hormone is stopped for less than 3 months.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

100 participants in 2 patient groups

50% dose of PDT
Experimental group
Description:
Patients received 50% dose of verteporfin PDT therapy.
Treatment:
Procedure: 50% dose of photodynamic therapy
70% dose of PDT
Experimental group
Description:
Patients received 70% dose of verteporfin PDT therapy.
Treatment:
Procedure: 70% dose of photodynamic therapy

Trial contacts and locations

1

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Central trial contact

Yuou Yao, Dr; Mingwei Zhao, Dr

Data sourced from clinicaltrials.gov

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