Different Hemostasis According to the Anesthetic Agents

Seoul National University

Status: Completed

Conditions: Cataract; Retina Detachment; Pterygium; Vitreous Hemorrhage; Keratitis

Treatments: Drug: Propofol, remifentanil; Drug: Sevoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT02151305

ROTEM_anesthesia

Details and patient eligibility

About

We investigated the hemostatic differences according to the main anesthetic agents by analyzing rotational thromboelastometry (ROTEM) under the hypothesis that propofol-based anesthesia would impair postoperative coagulability more than the sevoflurane-based anesthesia.

Enrollment: 66 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patient scheduled for ophthalmic surgery under general anesthesia
• American Society of Anesthesiologist physical status I or II

Exclusion criteria

• hematologic disorder
• severe anemia
• liver disease
• kidney disease
• taking a medication interfering with hemostasis

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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66 participants in 2 patient groups

Total intravenous anesthesia group

Experimental group

Description:

This group received propofol and remifentanil for the maintenance of general anesthesia.

Treatment:

Drug: Propofol, remifentanil

Inhalation anesthesia group

Experimental group

Description:

This group received sevoflurane for the maintenance of general anesthesia.

Treatment:

Drug: Sevoflurane