Different Hemostatic Agents Used in Partial Pulpotomy on Pulp Survival and Postoperative Pain

Çukurova University

Status: Not yet enrolling

Conditions: Postoperative Pain; Partial Pulpotomy; Efficacy of Hemostatic Agents

Treatments: Drug: Chlorhexidine; Drug: Sodium Hypochlorite 2,5%; Drug: Cold Saline

Study type: Interventional

Funder types: Other

Identifiers

NCT07058727

PP-HemoRCT-2025

Details and patient eligibility

About

This randomized clinical trial evaluates the efficacy of sodium hypochlorite (NaOCl), chlorhexidine (CHX), and cold saline as hemostatic agents in partial pulpotomy. The study compares postoperative pain (via VAS scores) and pulp survival (via clinical/radiographic evaluation) at 1, 3, 7 days, 6 months, and 12 months

Enrollment: 75 estimated patients

Sex: All

Ages: 15 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Permanent teeth with carious pulp exposure (no spontaneous pain).
• Positive vitality test (Endo-Ice).
• No periapical radiolucency.

Exclusion criteria

• Systemic diseases affecting healing.
• Pregnancy.
• Non-vital pulp/necrosis

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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75 participants in 3 patient groups

Arm 1

Experimental group

Description:

2.5% NaOCl applied for 1 min after pulp exposure.

Treatment:

Drug: Sodium Hypochlorite 2,5%

Arm 2

Experimental group

Description:

2% CHX applied for 1 min

Treatment:

Drug: Chlorhexidine

Arm 3

Experimental group

Description:

Hemostasis achieved with 4°C saline for 1 min.

Treatment:

Drug: Cold Saline