Different Lipid Emulsions in Acute Lung Injury Patients
Status and phase
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Study type
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Details and patient eligibility
About
Aim is to investigate the influence of an early supply of parenteral nutrition including a fish oil containing lipid emulsion on the course of acute lung injury in the intensive care unit. In comparison, a standard parenteral nutrition with a soybean oil based emulsion will be used. Data obtained in this trial may provide evidence for a beneficial effect of fish oil derived omega-3 fatty acids in parenteral nutrition regarding their influence on acute lung injury.
Enrollment
Sex
Ages
Volunteers
Inclusion and exclusion criteria
Inclusion:
- Acute Lung Injury as a result of proven pneumonia (x-ray) or witnessed aspiration
- Oxygenation factor ≤ 300
- <= 72 hours since intubation or non-invasive ventilatory support by mask at screening
- Expected need for parenteral nutrition for at least 5 days
- Male or female ≥ 18 years of age
Exclusion:
- Exclusion of pregnancy in women with child-bearing potential
- Cardiogenic pulmonary oedema
- Previous (< 1 month) or ongoing need for corticosteroids >0.1 mg/kg/d prednisolon-equivalent or other immune suppressive treatment
- Active or previous (< 1 year) treatment for solid or haematologic malignancy
- Serum triglycerides > 300 mg/dl at screening
- Alterations of coagulation (thrombocytes <100 Giga/l), aPTT > 60 sec, INR ≥ 2.5 without therapeutic intervention
- Autoimmune disease or HIV (according to medical history)
- Known or suspected drug abuse
- General contraindications to infusion therapy :
Trial design
Primary purpose
Allocation
Interventional model
Masking
1 participants in 2 patient groups
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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