Different Lipid Soluble Opioids for Gynecologic Laparoscopic Surgery Postoperative Patient-controlled Analgesia

Peking University

Status: Completed

Conditions: Post Operative Pain Management

Treatments: Drug: Sufentanil (R30730, brand name Sufenta) + Morphine; Drug: Morphine; Drug: Sufentanil (R30730, brand name Sufenta)

Study type: Interventional

Funder types: Other

Identifiers

NCT01917045

LSOPCA-021

Details and patient eligibility

About

The investigators noticed that Body Fat Ratio might have great influence on the efficacy of different lipid soluble anesthetics. The objective of this clinical trial was to compare the effect of that Body Fat Ratio on the efficacy of different lipid soluble anesthetics.

Full description

The objective of this clinical trial was to compare the effect of that Body Fat Ratio on the efficacy of different lipid soluble anesthetics.

Enrollment: 180 patients

Sex: Female

Ages: 20 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists grade I-II
• adults aged over 20 and below 50 years old,
• non-smoker,
• with normal hepatic and renal function.

Exclusion criteria

• smoker ,
• any kind of mental disorder or
• history use of analgesics for more than 10 consecutive days,
• asthma; and
• those with digestion tract disorder who would get nausea or vomiting much more easily than normal people.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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180 participants in 2 patient groups

low body fat percentage

Experimental group

Description:

body fat percentage less than 30%

Treatment:

Drug: Sufentanil (R30730, brand name Sufenta) + Morphine

Drug: Morphine

Drug: Sufentanil (R30730, brand name Sufenta)

heigh body fat percentage

Experimental group

Description:

body fat percentage more than 30%

Treatment:

Drug: Sufentanil (R30730, brand name Sufenta) + Morphine

Drug: Morphine

Drug: Sufentanil (R30730, brand name Sufenta)