Different Local Anesthetic Volumes for TPVB in Post-thoracotomy Analgesia

Ankara City Hospital

Status: Enrolling

Conditions: Postoperative Analgesia; Thoracotomy; Local Anesthetic; Thoracic Paravertebral Block; Acute Pain

Treatments: Procedure: TPVB with 25 ml; Procedure: TPVB with 30 ml; Procedure: TPVB with 20 ml

Study type: Interventional

Funder types: Other

Identifiers

NCT05700357

E.Kurul-E1-22-3143

Details and patient eligibility

About

Thoracotomy is one of the most painful operations known. Therefore, it causes severe acute pain. If pain is not controlled, it increases the frequency of postoperative pulmonary complications and postoperative morbidity. It can even cause chronic pain in the future. Thoracic epidural analgesia (TEA) is the gold standard method in the treatment of pain after thoracotomy. Thoracic paravertebral block (TPVB) is known as the most effective method after TEA. The fact that TPVB has fewer side effects than TEA increases the use of TPVB. There is no consensus on the dose of analgesia in studies. In the literature, volumes between 20 ml and 30 ml are frequently used for TPVB in recent years. This study, it was aimed to compare the efficacy of 20 ml, 25 ml, and 30 ml volumes of TPVB with local anesthetic at the same concentration (0.25% bupivacaine) on postoperative analgesia in patients undergoing thoracotomy.

Enrollment: 75 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18 to 80 years old
• American Society of Anesthesiologists (ASA) physical status I-II-III
• BMI 18 to 40 kg/m2
• Elective thoracotomy surgery

Exclusion criteria

• Patient refusing the procedure
• Emergency surgery
• History of chronic opioid or analgesic used

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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75 participants in 3 patient groups

Thoracic Paravertebral Block 20 ml

Active Comparator group

Description:

In patients who are planned to have a thoracic paravertebral block, the needle will be advanced to the paravertebral area with ultrasound-guided in-plane technique. 20 ml of 0.25% bupivacaine will be injected into this area.

Treatment:

Procedure: TPVB with 20 ml

Thoracic Paravertebral Block 25 ml

Active Comparator group

Description:

In patients who are planned to have a thoracic paravertebral block, the needle will be advanced to the paravertebral area with ultrasound-guided in-plane technique. 25 ml of 0.25% bupivacaine will be injected into this area.

Treatment:

Procedure: TPVB with 25 ml

Thoracic Paravertebral Block 30 ml

Active Comparator group

Description:

In patients who are planned to have a thoracic paravertebral block, the needle will be advanced to the paravertebral area with ultrasound-guided in-plane technique. 30 ml of 0.25% bupivacaine will be injected into this area.

Treatment:

Procedure: TPVB with 30 ml