Different Modalities in Reducing Airborne Particulate Concentrations During AGP for Health Volunteers

Rush

Status: Completed

Conditions: Transmission, Patient-Professional

Treatments: Device: Filter; Device: Scavenger face tent

Study type: Interventional

Funder types: Other

Identifiers

NCT04681599

AGP aerosol 002

Details and patient eligibility

About

Several clinical procedures have been described as aerosol generating procedure (AGP), including nebulization, high-flow nasal cannula oxygen therapy, noninvasive ventilation, and bronchial hygiene treatment, etc. However, the understanding on the transmission risk of these treatments is still unclear, particularly the methods to reduce the airborne particulate concentrations during these treatments are still lacking. This study is aimed to compare different modalities in reducing airborne particulate concentrations during these aerosol generating procedures, in order to find the most effective method to reduce particle concentrations, ultimately to decrease the transmission risk and protect health care providers.

Enrollment: 18 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Ages 18-65, Male or Female

Exclusion criteria

• Chronic lung disease, including asthma, COPD, etc.
• Upper airway anatomical abnormities
• Pregnancy
• Uncontrolled Diabetes, hypertension, or untreated thyroid disease
• Has any of the following symptoms in the last 21 days: sore throat, cough, chills, body aches for unknown reasons, shortness of breath for unknown reasons, loss of smell, loss of taste, fever at or greater than 100 degrees Fahrenheit.
• COVID-19 test positive within 21 days.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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18 participants in 5 patient groups

Nebulization without filter or scavenger

No Intervention group

Description:

Subject will use a standard nebulizer

Nebulization with a filter or scavenger

Experimental group

Description:

Subject will use a nebulizer with a filter placed at the other end of nebulizer mouthpice or a scavenger outside the nebulizer mask

Treatment:

Device: Scavenger face tent

Device: Filter

High-flow nasal cannula

No Intervention group

Description:

Subject will use high-flow nasal cannula at 40 L/min

High-flow nasal cannula with a scavenger face tent

Experimental group

Description:

Subject will use high-flow nasal cannula at 40 L/min, with a scavenger face tent

Treatment:

Device: Scavenger face tent

High-flow nasal cannula with a surgical mask

Active Comparator group

Description:

Subject will use high-flow nasal cannula at 40 L/min, with a surgical mask over nasal cannula

Treatment:

Device: Filter