Different Modes of Ventilation During Cardiopulmonary Bypass

Ain Shams University

Status: Completed

Conditions: Postoperative Pulmonary Dysfunction

Treatments: Device: Pressure controlled ventilation; Device: Volume controlled ventilation

Study type: Interventional

Funder types: Other

Identifiers

NCT03824301

ASCSH32/17

Details and patient eligibility

About

66 patients divided into 3 groups with different modes of ventilation.

Full description

Sixty-six patients going through open-heart surgeries were included in the study, divided into 3 groups (P: pressure controlled ventilation, V: volume controlled ventilation, C: control) in accordance with the mode of ventilation. Patients studied for chest x-ray, lung ultrasound, arterial oxygen partial pressure to fractional inspired oxygen ratio (PaO2/FiO2), Alveolar-arterial oxygen gradient, static lung compliance and dynamic lung compliance, taken after induction of anesthesia, 1h post cardiopulmonary bypass, 1h after arrival to cardiac surgical unit.

Enrollment: 66 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoingvalve surgeries
• Patients undergoing coronary artery bypass grafting surgeries

Exclusion criteria

• Emergency cases.
• Off-pump surgeries.
• Patients with chronic lung diseases with forced expiratory volume in first second (FEV1) or forced vital capacity (FVC) less than 40% of the predicted value.
• Massive blood transfusion during surgery.
• Complicated surgeries.
• Redo surgeries.
• Patients with decompensated heart failure prior to surgery.
• Patients refusal

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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66 participants in 3 patient groups

Volume-controlled ventilation

Active Comparator group

Description:

During cardiopulmonary bypass period the patients were ventilated with volume-controlled ventilation

Treatment:

Device: Volume controlled ventilation

Pressure-controlled ventilation

Active Comparator group

Description:

During cardiopulmonary bypass period the patients were ventilated with pressure-controlled ventilation

Treatment:

Device: Pressure controlled ventilation

No ventilation

No Intervention group

Description:

During cardiopulmonary bypass period the patients were disconnected from ventilator