Different Oils For Frying and Endothelial Function

Andalusian Health Service

Status: Completed

Conditions: Endothelial Dysfunction

Treatments: Dietary Supplement: Olive Oil, SF, SF+DMP, SF+phenols

Study type: Interventional

Funder types: Other

Identifiers

NCT00837317

Oils&Frying

Details and patient eligibility

About

The purpose of this study is to compare the effects of the consumption of different oils (olive oil, sunflower oil, sunflower plus dimethyl-polysiloxane, sunflower plus phenols) previously submitted to heating in postprandial endothelial function, inflammation and oxidative stress in healthy young men.

Full description

To determine whether the consumption by healthy persons of an oil exposed to high temperatures, designed to have a composition of healthy fats (predominantly monounsaturated fats and with less than 10% palmitic acid) and to contain an abundance of antioxidants typically found in olive oil (phenolic compounds), will improve the vasodilatory response that depends on the endothelium, and buffer the inflammatory and postprandial oxidative response that is produced by the oils that are being used ever more frequently for frying purposes (sunflower oil and oil to which butylated hydroxytoluene (BHT) has been added), using virgin olive oil exposed to the same heating regime as a reference oil.

Enrollment: 26 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Investigators will select obese people (BMI ranged 25 to 40).

Exclusion criteria

• Evidence of malignancy or severally ill (life expectancy lesser than 5 years).

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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26 participants in 1 patient group

1

Experimental group

Description:

All the volunteer subjects will be administered four breakfast meals that have been prepared with four different types of oil, each of which will have been subjected to a standardised frying. The meals will be administered according to a cross-randomized Latin squares design

Treatment:

Dietary Supplement: Olive Oil, SF, SF+DMP, SF+phenols