Different PEEP Settings of COVID-19 Induced ARDS

Southeast University, China

Status: Completed

Conditions: Mechanical Ventilation Pressure High; COVID-19; Acute Respiratory Distress Syndrome

Treatments: Other: Hemodynamics changes at different PEEP; Other: lung mechanics at different PEEP; Other: Gas exchanges at different PEEP

Study type: Interventional

Funder types: Other

Identifiers

NCT04359251

COVID-19 PEEP titration

Details and patient eligibility

About

This was a multi-center prospective study. All consecutive severe cases of COVID-19 whose PO2/FiO2<300mmHg with invasive ventilation admitted to 5 fixed-point receive COVID-19 patients hospitals in Wuhan from 5 March to 15 March 2020 were included. Epidemiological, clinical data, lung mechanics, artery blood gas test and hemodynamics at three methods to titrate PEEP, optimizing oxygenation, optimizing compliance, ARDSnet. The study was approved by the Ethics Committee of Zhongda Hsopital, Southeast University.

Full description

After PEEP titration, PEEP settings could be set by optimizing oxygenation, optimizing compliance, ARDSnet.

Enrollment: 20 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• COVID-19 patients with mechanical ventilation
• PO2/FIO2<300mmHg
• ages>18 years

Exclusion criteria

• pneumothorax
• pregnant
• hemodynamics is unstable

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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20 participants in 3 patient groups

Optimizing oxygenation

Experimental group

Description:

Best oxygenation during PEEP titration

Treatment:

Other: Gas exchanges at different PEEP

Optimizing compliance

Experimental group

Description:

Best compliance during PEEP titration

Treatment:

Other: lung mechanics at different PEEP

ARDSnet

Experimental group

Description:

PEEP settings according to ARDSnet table

Treatment:

Other: Hemodynamics changes at different PEEP