Different Regulation of Immune Cells in Patients With Preeclampsia

University Medical Center Groningen (UMCG)

Status: Unknown

Conditions: Preeclampsia; Pregnancy

Treatments: Procedure: Blood withdrawal

Study type: Observational

Funder types: Other

Identifiers

NCT02691364

2015/612

Details and patient eligibility

About

Adaptation of the maternal immune system to accommodate the semi-allogeneic fetus is necessary for pregnancy success. Dysregulation of this immune adaptation is implicated in reproductive disorders as infertility, recurrent miscarriage, fetal growth restriction, and preeclampsia. The mechanisms being responsible for fetal tolerance are not known. Several T cell subsets have been implicated in fetal tolerance. The effects of preeclampsia on memory cells are not known. The main objective of this study is to analyze the effect of preeclampsia on levels of immune cells.

Enrollment: 30 estimated patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• healthy
• written informed consent
• 18-40 years

Exclusion criteria

• smoking
• immune related disorders (other than preeclampsia)
• fever / illness within the last month
• infertility
• body mass index <18 or >30

Trial design

30 participants in 2 patient groups

Healthy

Description:

Healthy women

Treatment:

Procedure: Blood withdrawal

Preeclamptic

Description:

Pregnant women with preeclampsia

Treatment:

Procedure: Blood withdrawal