Different Regulation of Immune Cells in Patients With Preeclampsia

U

University Medical Center Groningen (UMCG)

Status

Unknown

Conditions

Preeclampsia
Pregnancy

Treatments

Procedure: Blood withdrawal

Study type

Observational

Funder types

Other

Identifiers

NCT02691364
2015/612

Details and patient eligibility

About

Adaptation of the maternal immune system to accommodate the semi-allogeneic fetus is necessary for pregnancy success. Dysregulation of this immune adaptation is implicated in reproductive disorders as infertility, recurrent miscarriage, fetal growth restriction, and preeclampsia. The mechanisms being responsible for fetal tolerance are not known. Several T cell subsets have been implicated in fetal tolerance. The effects of preeclampsia on memory cells are not known. The main objective of this study is to analyze the effect of preeclampsia on levels of immune cells.

Enrollment

30 estimated patients

Sex

Female

Ages

18 to 40 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • healthy
  • written informed consent
  • 18-40 years

Exclusion criteria

  • smoking
  • immune related disorders (other than preeclampsia)
  • fever / illness within the last month
  • infertility
  • body mass index <18 or >30

Trial design

30 participants in 2 patient groups

Healthy
Description:
Healthy women
Treatment:
Procedure: Blood withdrawal
Preeclamptic
Description:
Pregnant women with preeclampsia
Treatment:
Procedure: Blood withdrawal

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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