Differential Acute Tolerance Development to Effects of Nitrous Oxide - 7

The University of Chicago

Status and phase: Completed; Phase 2

Conditions: Opioid-Related Disorders; Substance-Related Disorders

Treatments: Drug: Nitrous oxide

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00000255

R01-08391-7

R01DA008391 (U.S. NIH Grant/Contract)

NIDA-08391-7

Details and patient eligibility

About

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine differential acute tolerance development to effects of nitrous oxide in humans.

Enrollment: 10 patients

Sex: All

Ages: 21 to 37 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Please contact site for information.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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10 participants in 5 patient groups, including a placebo group

0% Nitrous oxide

Placebo Comparator group

Treatment:

Drug: Nitrous oxide

10% nitrous oxide

Active Comparator group

Treatment:

Drug: Nitrous oxide

20% nitrous oxide

Active Comparator group

Treatment:

Drug: Nitrous oxide

30% nitrous oxide

Active Comparator group

Treatment:

Drug: Nitrous oxide

40% nitrous oxide

Active Comparator group

Treatment:

Drug: Nitrous oxide