Differential Adaptation of Renal Function in Intense Physical Exercise

Hospital Clínico Universitario de Valladolid

Status: Completed

Conditions: Acute Kidney Injury

Treatments: Other: 10 km continuous running; Other: 1.5 km continuous swimming

Study type: Interventional

Funder types: Other

Identifiers

NCT04929418

GRS 1732A/18 (Other Grant/Funding Number)

PI-GR-18-914

Details and patient eligibility

About

In recent years there has been a significant increase in the number of participants in high intensity and duration sports events. This type of physical exercise has been reported to lead to an apparently transitory deterioration in kidney function. The injury mechanisms involved in this process have not been fully studied, but several have been proposed as potential causes, such as tissue ischemia, disruption of the permeability of the glomerular basement membrane, damage to the ultra-structure of skeletal muscle, structural involvement of the renal parenchyma, exercise-associated hyperthermia or insufficient hydration during exercise.

Urinary biomarkers, which are a more precise tool than serum creatinine when it comes to detecting subclinical kidney damage, may be key to elucidate the characteristics of exercise-related kidney injury.

The aim of this study is to carry out an integrative analysis of the development of exercise-associated subclinical acute kidney injury.

Enrollment: 40 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age ≥18 years.
• Able to understand the objectives of the study and to provide informed consent.
• Body mass index between 18.5 and 24.9 kg / m2
• Active sportsman/woman (defined as previous experience with the planned tests and performing vigorous-intensity aerobic activity at least three times per week).

Exclusion criteria

• History of chronic kidney disease, hypertension, uncontrolled diabetes (defined as fasting glucose levels ≥200 mg/dl or HbA1c ≥9%), peripheral vascular disease, heart disease, neurological disease or thyroid disease.
• Use of NSAIDs in the 72h prior to the test.
• Consumption of statins or anabolic steroids.
• Some kind of major physical injury in the four months prior to the tests.

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

10 km continuous running

Other group

Description:

Participants will perform a test of 10 km coninuous running.

Treatment:

Other: 10 km continuous running

Other: 1.5 km continuous swimming

1.5 km swimming

Other group

Description:

Participants will perform a test of 1.5 km coninuous swimming.

Treatment:

Other: 10 km continuous running

Other: 1.5 km continuous swimming