Differential Diagnosis of Pulmonary Hypertension With Automated Image Analysis

Medical University of Graz

Status: Terminated

Conditions: Pulmonary Hypertension

Treatments: Radiation: Thoracic computed tomography

Study type: Observational

Funder types: Other

Identifiers

NCT04329312

32-184 ex 19/20

Details and patient eligibility

About

The aim of the study is to determine relevant morphologic parameters of the lung vasculature for the differentiation between different groups of patients with pulmonary hypertension (PH) by thoracic computer tomography (CT). In this pilot study patients undergoing right heart catheterization will be investigated by thoracic CT and special software to determine morphologic readouts.

The investigators expect that using this non-invasive method, parameters relevant for the differentiation of the patients with PH can be determined.

Full description

Pulmonary hypertension (PH) is defined as an elevated mean pressure in the pulmonary artery above 20mmHg determined at right-heart catheterization. Depending on the presentation and pathogenesis, patients are classified according to five main groups. A correct classification is crucial, since it is essential for the available therapy options.

A promising non-invasive method to provide important hemodynamic and clinical Information is the fully-automatic analysis of thoracic computed tomography images. This method can yield a number of quantitative morphologic readouts of the lung vasculature and the parenchyma.

This study aims to identify quantitative markers from the fully-automatic image analysis, which allow a discrimination between the various PH patient groups.

Enrollment: 23 patients

Sex: All

Ages: 18 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with right-heart catheterization
• Clinical indication for thoracic CT

Exclusion criteria

• Pregnancy
• Decreased kidney function
• Intolerance to contrast material
• Other standard CT contraindications

Trial design

23 participants in 7 patient groups

Pulmonary arterial hypertension (PAH)

Description:

The patients with PAH received an invasive right-heart catheterization and a thoracic CT scan as part of their routine work up.

Treatment:

Radiation: Thoracic computed tomography

PH due to left-heart disease (PH-LHD)

Description:

The patients with PH-LHD received an invasive right-heart catheterization and a thoracic CT scan as part of their routine work up.

Treatment:

Radiation: Thoracic computed tomography

Chronic thromboembolic pulmonary hypertension (CTEPH)

Description:

The patients with CTEPH received an invasive right-heart catheterization and a thoracic CT scan as part of their routine work up.

Treatment:

Radiation: Thoracic computed tomography

PH due to emphysema (PH-LD-Emphys)

Description:

The patients with PH-LD-Emphys received an invasive right-heart catheterization and a thoracic CT scan as part of their routine work up.

Treatment:

Radiation: Thoracic computed tomography

PH due to lung fibrosis (PH-LD-Fibr)

Description:

The patients with PH-LD-Fibr received an invasive right-heart catheterization and a thoracic CT scan as part of their routine work up.

Treatment:

Radiation: Thoracic computed tomography

PH due to combined emphysema and fibrosis (PH-LD-CPFE)

Description:

The patients with PH-LD-CPFE received an invasive right-heart catheterization and a thoracic CT scan as part of their routine work up.

Treatment:

Radiation: Thoracic computed tomography

No PH

Description:

The patients without PH received an invasive right-heart catheterization and a thoracic CT scan as part of their routine work up.

Treatment:

Radiation: Thoracic computed tomography