Differential Effects of Lipids on Cardiovascular Diseases: A CALIBER Study

University College London (UCL)

Status: Unknown

Conditions: ST Elevation Myocardial Infarction; Unstable Angina; Stable Angina; Myocardial Infarction Not Otherwise Specified; Non ST Elevation Myocardial Infarction

Study type: Observational

Funder types: Other

Identifiers

NCT01687686

CALIBER-12-01

Details and patient eligibility

About

The role of lipids as risk factors for cardiovascular events is well-documented, although events studied have largely been broad classes without specific detail. This study will examine a more refined set of endpoints.

Full description

The role of lipids (cholesterol and triglycerides) as risk factors for cardiovascular events is well-documented. The Emerging Risk Factors Collaboration found approximately log-linear adjusted associations of cholesterol concentrations with risks of first-time non-fatal myocardial infarction; coronary heart disease (CHD) death; ischaemic, haemorrhagic and unclassified stroke. They also found that triglycerides concentration was not independently related with CHD risk after controlling for HDL cholesterol (HDL-C), non-HDL-C, and other standard risk factors. The Prospective Studies Collaboration found that Higher HDL-C and lower non-HDL-C levels were approximately independently associated with lower ischaemic heart disease mortality. By focusing on broad outcomes these large meta-analyses conflate the association between development of the different cardiovascular disease (CVD) phenotypes, disease progression and mortality from cardiovascular causes.

With linked electronic health records, we have the potential for a cohort with sufficient size and clinical detail to investigate the association between lipid concentrations and initial presentation of a range of CVD phenotypes across cerebral, coronary, abdominal and peripheral arterial circulations.

Enrollment: 175,872 patients

Sex: All

Ages: 30+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged 30 to 100, had at least one year of electronic health record data which meet General Practice Research Database data quality standards

Exclusion criteria

• No record indicating any cardiovascular disease phenotypes

Trial design

175,872 participants in 1 patient group

All cohort

Description:

Initially healthy patients in General Practise Research Database (GPRD) meeting the inclusion criteria at any point between 1st January 2001 and 25th March 2010