Differential Effects of Milk Proteins on Postprandial Lipemia in Response to a Fat-Rich Meal in Type 2 Diabetes

Aarhus University Hospital

Status: Completed

Conditions: Postprandial Lipemia; Type 2 Diabetes

Treatments: Dietary Supplement: Whey Hydrolysate; Dietary Supplement: Casein; Dietary Supplement: Alphalact-Albumin; Dietary Supplement: Whey Isolate

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00819975

CERN-PPL (5B) LSM

Details and patient eligibility

About

Enhanced and prolonged postprandial triglyceride responses involve increased cardiovascular risk in type 2 diabetes. It has been demonstrated that dietary fat and carbohydrates profoundly influence postprandial hypertriglyceridemia in type 2 diabetes, whereas little information exists about the effect of proteins.

The purpose of this study is to compare the effects of the milk proteins casein, Whey Isolate, Whey Hydrolysate, and Alphalact-Albumin on postprandial lipid and incretin responses to a high-fat meal in type 2 diabetes.

Enrollment: 12 patients

Sex: All

Ages: 40 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Type 2 Diabetes

Exclusion criteria

• Liver-, Kidney- and/or Heart Disease
• Serious Hypertension (160/110 mmHg)

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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12 participants in 4 patient groups

Casein

Active Comparator group

Treatment:

Dietary Supplement: Casein

Whey Isolate

Active Comparator group

Treatment:

Dietary Supplement: Whey Isolate

Whey Hydrolysate

Active Comparator group

Treatment:

Dietary Supplement: Whey Hydrolysate

Alphalact-Albumin

Active Comparator group

Treatment:

Dietary Supplement: Alphalact-Albumin