Differential Expression and Potential Value of c-MYC in Non-Invasive and Invasive Mammary Carcinoma

Marwa Mahmoud Hassan

Status: Invitation-only

Conditions: Invasive Breast Cancer

Treatments: Other: no intervention

Study type: Observational

Funder types: Other

Identifiers

NCT06357338

Soh-Med-24-03-15MS

Details and patient eligibility

About

Retrospective observational study to evaluate c-MYC expression in non invasive and invasive mammry carcinoma

Full description

To correlate different levels of c-MYC expressions with variable clinical and pathological parameters of mammary carcinoma (such as patients' ages, tumor grading, staging, laterality, focality and nodal metastasis, co-existing in-situ components). This study will be carried out on archived formalin-fixed and paraffin embedded tissue blocks that were belonged to 70 women with breast lumps.

Enrollment: 70 estimated patients

Sex: Female

Ages: 15+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Specimens of Modified Radical Mastectomies from breast carcinoma patients

Exclusion criteria

• Cases with insufficient clinical data.

  • Tissue blocks of destroyed or insufficient material, unfit for diagnosis.
  • Cases who received pre-operative chemotherapy.

Trial design

70 participants in 2 patient groups

non invasive mammary carcinoma

Description:

35 cases with non invasive breast cancer with low and high nuclear grades and co existing microfoci of invasion

Treatment:

Other: no intervention

invasive mammary carcinoma

Description:

35 cases of invasive breast cancer undergone MRM and classify them according grading, staging and luminal subtypes

Treatment:

Other: no intervention