Differential Plasma MicroRNA Profiles in ED and Normal Erectile Function in Older Males

Nanjing Medical University

Status: Unknown

Conditions: Erectile Dysfunction

Treatments: Other: Take blood

Study type: Observational

Funder types: Other

Identifiers

NCT01830049

2013024 (Other Identifier)

NJU2013024

Details and patient eligibility

About

Erectile dysfunction (ED) is strongly associated with aging. With the rapidly expanding aging population and the increase in life expectancy, an increase in the prevalence of ED is expected in the years to come. Currently, the mechanism of ED is not fully understood. MicroRNAs (MiRNA) are endogenous small RNA molecules that control gene expression post-transcriptionally. It has been included in many in vitro physiology and pathophysiology processes, which also involved in the process of ED. This research was designed to investigate the differential plasma MiRNA profiles in ED and normal erectile function in older males. The results might tell us which MiRNA and how did it involved in the process of ED in aging.

Enrollment: 30 estimated patients

Sex: Male

Ages: 20 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• older males with erectile dysfunction

Exclusion criteria

• have some other general diseases, e.g. hypertension, vascular diseases, depression, chronic kidney disease, diabetes.

Trial design

30 participants in 3 patient groups

Group I

Description:

Older males with ED

Treatment:

Other: Take blood

Group II

Description:

Older males with normal erectile function

Treatment:

Other: Take blood

Gourp III

Description:

Young males with normal rectile function

Treatment:

Other: Take blood