Differential Study of Muscle Transcriptome (TRANE)

Assistance Publique - Hôpitaux de Paris

Status: Completed

Conditions: ALS; SBMA; SMA

Treatments: Procedure: Muscle biopsy

Study type: Interventional

Funder types: Other

Identifiers

NCT01984957

P110401

Details and patient eligibility

About

To isolate biomarkers of ALS in muscle

Full description

At present, there is no validated biological diagnostic marker for amyotrophic lateral sclerosis (ALS). The main objective of the study is to isolate a set of genes that are specifically dysregulated in muscle from ALS patients.

Gene profiling in muscle will be compared between ALS patients and patients with other motor neuron diseases (SMA and SBMA)

Enrollment: 42 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria :

• Patient with ALS, SMA, or SBMA

Exclusion criteria :

• Indication against biopsy (allergy to anesthetics local haemostasis disorders)
• Treatments that can affect muscle metabolism

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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42 participants in 1 patient group

disease (ALS, SMA or SBMA)

Other group

Description:

muscle biopsy

Treatment:

Procedure: Muscle biopsy