Differentiating Tumor-stroma Ratio in Pancreatic Ductal Adenocarcinoma

Chongqing Medical University

Status: Active, not recruiting

Conditions: Pancreatic Ductal Adenocarcinoma

Study type: Observational

Funder types: Other

Identifiers

NCT06302881

liaohongfan

Details and patient eligibility

About

This study introduces a novel transfer learning-based contrastive language-image pretraining adapter (CLIP-adapter) model for predicting the tumor-stroma ratio (TSR) in pancreatic ductal adenocarcinoma (PDAC) using preoperative dual-phase CT images. The primary aim is to develop an efficient and accessible tool for risk stratification and personalized treatment planning.

Full description

The proposed novel Contrastive Language-Image Pretraining-Adapter (CLIP-adapter) model, leveraging transfer learning, framing CLIP and a self-attention mechanism for predicting TSR in PDAC, in order to exhibit high performance in distinguishing low and high TSR PDAC in the test cohort. We speculated the CLIP-adapter model outperformed single-phase models, specifically CLIP models based on arterial or venous phase images alone. The addition of a feature fusion module could enhance the model's differentiation capacity, emphasizing its superiority over single-phase models. Besides, the model we designed utilized both image and text information during network training, instead of focusing on images only. This underscores the importance of comprehensive assessment in PDAC imaging evaluation, with the potential to contribute to risk stratification and personalized treatment planning.

Enrollment: 207 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

1. patients with pathologically proven PDAC by surgical resection
2. patients who underwent CT scan within a month before surgery
3. observable pancreatic lesions on available images.

Exclusion criteria

1. any anti-cancer therapy before CT scanning
2. conspicuous interference or significant motion distortions found on images
3. partial clinical data
4. patients with liver metastases or peritoneal carcinomatosis prior to surgical intervention.

Trial design

207 participants in 1 patient group

low TSR and high TSR group

Description:

The assessment of the tumor-stroma ratio (TSR) entailed measuring the percentage of tumor and stroma constituents. Based on earlier research, 5/5 was deemed as ideal threshold of TSR measurement.