Diffrence in Thromboprofilaksis in Elderly Ostoepenic Hip Fractures According to Mobility Status by Genetic Analysis (HSP 47)

Saglik Bilimleri Universitesi

Status: Enrolling

Conditions: Osteopenia; Hip Fracture of Intertrochanteric Type; Thromboembolic Event; Thrombosis Embolism

Treatments: Genetic: Gene Expression Analysis

Study type: Interventional

Funder types: Other

Identifiers

NCT06959017

01.04.2024-65

Details and patient eligibility

About

Hip fracture is a common and severe disease in elderly patients. The question of the study is whether elderly patients with severe osteopenia have significantly lower levels of the collagen-binding protein Hsp47 than relatively mobile patients due to advanced immobility before the fracture, and whether they participants have a similar risk of VTE to the normal population despite having had a hip fracture and surgery.

Full description

In this study, the investigators aimed to prospectively measure the Hsp 47 gene expression levels in patients scheduled for surgery due to intertrochanteric femur fracture and healthy volunteers in the same age group and compare the results with the literature.

Also the complications prior or after surgery will be compared.

Enrollment: 90 estimated patients

Sex: All

Ages: 65+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• >65 years of age
• Interthrocanteric femur fracture AO Type 31A1, 31A2, 31A3
• Patients treated proksimal femoral nail
• Minor trauma
• Fracture mobility score 1,2,3,4,5
• Inial thrombocytes count 150.000-450.000 /µL

Exclusion criteria

• Body mass index >40
• Fracture mobility score 6 (unknown type)
• stage 4 chronic kidney disease
• Patients with rheumatological diseases
• Patients at serious risk of VTE(Venous thromboembolism) (according to the International Society on Thrombosis and Hemostasis, categorization of venous thromboembolism) :
• Active Hematologic Cancer
• Antiphospholipid syndrome
• History of recurrent thrombosis (DVT)
• Paroxysmal nocturnal hemoglobinuria

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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90 participants in 3 patient groups

Group 1

Active Comparator group

Description:

This group is consist of the patients with pre-fracture mobility score 3-4-5

Treatment:

Genetic: Gene Expression Analysis

Group 2

Experimental group

Description:

This group is consist of the patients with pre-fracture mobility score 1-2

Treatment:

Genetic: Gene Expression Analysis

Group 3

Experimental group

Description:

This group is consist of the volunteered healty people which \>65 years of age

Treatment:

Genetic: Gene Expression Analysis