Diffusion MRI for Quantitative Assessment of Myofascial Pain

Weill Cornell Medicine (WCM)

Status: Enrolling

Conditions: Masticatory Myofascial Pain Syndrome

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT06892041

R61AT012270 (U.S. NIH Grant/Contract)

24-07027694

Details and patient eligibility

About

The purpose of this study is to assess the diagnostic accuracy of diffusion MRI for evaluation of the jaw muscles for patients with masticatory myofascial pain syndrome.

Enrollment: 90 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Men and women 18-65 years of age
• Ability to give informed consent
• Symptoms meeting criteria for normal or latent/active temporomandibular myofascial pain

Exclusion criteria

• Contraindications to MRI scanning including severe obesity or difficulty in laying in a supine position, intracranial clips, metal implants, external metallic devices/objects/clips within 10mm of the head, suspected or confirmed metal in the eyes (history of welding or similar activity), claustrophobia, cardiac pacemaker or pacing wires
• Pregnancy or breast feeding
• Traumatic injury of masticatory muscles or temporomandibular joint within last 12 months
• Mandibular fracture within last 12 months
• Initiation of additional treatment of myofascial pain within the past 1 month
• Received masseter Botox within the last 4 months

Trial design

90 participants in 2 patient groups

Normal

Description:

Subjects without masticatory myofascial pain syndrome

Latent/Active Pain Stage

Description:

Subjects with latent or active masticatory myofascial pain syndrome