Diffusion Tensor Imaging of Median Nerve in Diabetic Peripheral Neuropathy

Cairo University (CU)

Status: Completed

Conditions: Diabetic Polyneuropathy; Magnetic Resonance Imaging

Treatments: Diagnostic Test: Diffusion tensor imaging of peripheral nerves

Study type: Observational

Funder types: Other

Identifiers

NCT03934970

19/04/15

Details and patient eligibility

About

This study is a diagnostic accuracy study that aims to evaluate the role of DTI in evaluation of DPN in comparison to clinical scores and nerve conduction studies (NCS). The study included 30 patients with diabetes mellitus complaining of neuropathy symptoms and 15 healthy volunteers. All subjects underwent evaluation using 1.5T DTI of median nerves and NCS. Patients underwent clinical evaluation using Neuropathy Deficit Score (NDS), Neuropathy Impairment Score in the Lower Limbs (NIS-LL) and Diabetic Neuropathy Examination (DNE) score. The values of these tests were compared and correlated and diagnostic accuracy tests were performed together with identification of cut-off score for abnormal diffusion tensor imaging parameters in diabetic neuropathy

Enrollment: 45 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Diabetic patients with symptoms suggestive of peripheral neuropathy.

Exclusion criteria

• Patients with evidence of nerve entrapment or neuropathy due to causes other than DM

Trial design

45 participants in 2 patient groups

Diabetic Neuropathy

Description:

Thirty Egyptian patients with type 2 diabetes mellitus complaining of symptoms suggestive of peripheral neuropathy including 12 males and 18 females with a mean of 50.90 ± 9.18.

Treatment:

Diagnostic Test: Diffusion tensor imaging of peripheral nerves

Healthy Control Subjects

Description:

Fifteen normal healthy Egyptian volunteers including10 males and 5 females with a mean age of 45.67±7.77 years.

Treatment:

Diagnostic Test: Diffusion tensor imaging of peripheral nerves