Diffusion Tensor Imaging to Assess the Functional Outcomes of Adults With Cervical Spinal Cord Injuries

The Washington University

Status: Withdrawn

Conditions: Cervical Spinal Cord Injury

Study type: Observational

Funder types: Other

Identifiers

NCT01712698

Washington University (Other Identifier)

DTI

Details and patient eligibility

About

Acute changes in axial diffusivity will correlate with the severity of injury in patients that suffer an acute spinal cord injury.

Full description

Diffusion tensor imaging (DTI) parameters will correlate with severity of spinal cord injury in SCI patients as seen in rodent models. We will test whether the quantitative decrease in axial (λ║) diffusivity (a biomarker of axonal injury), will predict long-term functional outcomes for patients with a SCI.

Specific Aim: To examine patients after an acute SCI using DTI and to correlate the extent of acute decrease in λ║ with the presenting ASIA motor score and long-term functional outcome of the patient.

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18-65 years of age
• Cervical spinal cord injury
• physically and mentally willing to comply with imaging
• lives in immediate area with no plans to relocate

Exclusion criteria

• Associated moderate to severe head injury
• Active malignancy
• Previous spinal cord injury
• pregnancy
• inability to tolerate MRI scanning

Trial design

0 participants in 1 patient group

Cervical spinal cord injury

Description:

Those patients with an acute cervical spinal cord injury evaluated with DTI MRI