Diffusion Weighted Magnetic Resonance Imaging for Preoperative Staging in Gastric Adenocarcinoma Patients

B

Bezmialem Vakif University

Status and phase

Completed
Early Phase 1

Conditions

Gastric Adenocarcinoma

Treatments

Procedure: diffusion weighted magnetic resonance imaging

Study type

Interventional

Funder types

Other

Identifiers

NCT01794026
DWMRIGASTADENO

Details and patient eligibility

About

Preoperative staging for gastric adenocarcinoma is an important procedure to detect advanced disease stateS for the patients in which the surgery may be unnecessary to perform. Although there are many imaging techniques for this purpose, sensitivity and specificity of these techniques still remains to be low.Preoperative detection of peritoneal carcinomatosis and involvement of lymph nodes beyond D2 may prevent surgical procedures. Removal of the determined lymph nodes according to the type of the surgery is the accepted surgical method. However, accurate determination of malignant lymph nodes may prevent dissection of some groups of the lymph nodes. These findings may cause a new definition of gastric lymph node dissection.

Full description

proven endoscopic diagnosis of gastric adenocarcinoma for staging purposes, computed tomography for all patients evaluation of benign and malignant lymph nodes according to computed tomography findings and mapping of the lymph nodes to state precisely resectable patients according to computed tomography and anesthetic evaluation evaluation of benign and malignant lymph nodes according to diffusion weighted magnetic resonance imaging findings and mapping of the lymph nodes standard gastrectomy and D2 lymph node dissection mapping of the lymph nodes after taking the specimen out histopathological diagnosis of the lymph nodes and mapping comparison of the results taken from computed tomography, diffusion weighted magnetic resonance imaging and histopathological analysis

Enrollment

30 patients

Sex

All

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • gastric adenocarcinoma proven by endoscopic biopsy;
  • application of both computed tomography and diffusion weighted magnetic resonance imaging;
  • standard gastrectomy and a D2 lymph node dissection;
  • desire to attend the study protocol

Exclusion criteria

  • preoperative neoadjuvant therapy;
  • metastatic disease;
  • undesired reaction to attend the study protocol

Trial design

Primary purpose

Diagnostic

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

30 participants in 1 patient group

diffusion MRI
Experimental group
Description:
histopathology of lymph nodes diagnosed by diffusion weighted magnetic resonance imaging
Treatment:
Procedure: diffusion weighted magnetic resonance imaging

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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