Digestive Biobank for Exploring Microbiota-host Interactions (BiomHost)

Assistance Publique - Hôpitaux de Paris

Status: Enrolling

Conditions: Ulcerative Colitis; Inflammatory Bowel Diseases; Indeterminate Colitis; Crohn Disease; Colorectal Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT05704413

APHP180540

Details and patient eligibility

About

Constitution of a biobank of tissues, whole blood and plasma samples and stools to identify markers associated with treatment response, postoperative morbidity including neuro-cognitive and mood complications and prognosis of Inflammatory Bowel disease or colorectal cancer.

Full description

Inflammatory Bowel disease (Crohn, Ulcerative colitis) and colorectal cancer are frequent affections and the microbiota plays a major role in their physiopathology involving the immune system. In this setting, the interplay between gut microbiota and brain is still unexplored.

To evaluate the interaction of the microbiota and the immune system with the host in these two chronic diseases, we aim to create a prospective biobank.

A small amount of tissue will be taken during surgery. A whole blood, plasma and stoll samples will also be taken from the patient.

All samples will be anonymized.

Enrollment: 500 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Ulcerative colitis, Crohn's disease or colorectal disease
• Digestive resection with useless tissue available
• Information consent signed

Exclusion criteria

• Patients < 18 years

Trial design

500 participants in 1 patient group

digestive cancer or IBD

Description:

Patient with digestive cancer or IBD having surgery with intestinal resection planned in the Visceral Surgery Department of St Antoine Hospital